Author: Jasmine He

How Long Does Vyvanse Stay In Your System?

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Vyvanse is a psychostimulant medication used to stimulate central nervous system (CNS). The kind of medication is applied to treat ADHD (hyperactivity disorder or attention-deficit) and binge eating disorders or other cases of depression. Like most drugs used to stimulate the central nervous system, Vyvanse has addictive properties. The abuse of this psychostimulant medication can result in severe health problems and be life-threatening. It is quite hard to answer “How long does Vyvanse stay in your system?”. Therefore, if you are concerned about the side effects of the drug, in this article, we will help you answer this question.

What Is Vyvanse?

Vyvanse is also known as lisdexamfetamine. After Vyvanse is taken, it works by balancing chemicals in the brain to help an ADHD child with impulse control and hyperactivity. Vyvanse is usually used to treat ADHD children (more than six-years-old) or in adults with the nervous condition. As mentioned above, Vyvanse can affect your central nervous system owing to its addictive nature if the medication is taken in a long-term. You should take the psychostimulant medication as you get a prescription from your doctor.

How does Vyvanse work in the body?

Dopamine and norepinephrine are the two neurotransmitters keep ADHD patients mentally alert, enhancing focus ability and maintaining thought, motivation, and effort. Vyvanse works by stimulating the release of these neurotransmitters from the presynaptic nerve terminals. The medication contains Lisdexamfetamine, a psychostimulant drug called Dextroamphetamine. Dextroamphetamine acts as both a VMAT2 inhibitor and a TAAR1 agonist. It is believed Dextroamphetamine works together with DAT or dopamine and norepinephrine transporters, which promotes neurophysiological arousal and support conditions including ADHD, binge eating disorder, as well as some other cases of depression. It explains why ADHD patients who have taken Vyvanse feel smoother often.

How Long Does Vyvanse Stay in Your System?

Many people decide to stop taking the psychostimulant medication due to its addictive nature and long-term side effects. Below we will give you the answer to the question how long does Vyvanse stay in your system.

It is estimated that Vyvanse’s elimination half-life is under an hour (many sources suggest ~47 minutes). It means 50% of Vyvanse ingested dose is eliminated from the body systems in around an hour. The main ingredient Lisdexamfetamine will take from 4.3 to 5.5 hours to be completely excreted. However, this does not mean that the metabolites of Lisdexamfetamine will also have been cleared. Lisdexamfetamine will metabolize to dextroamphetamine (and L-Lysine).  Dextroamphetamine need a much longer half-life to be excreted in comparison with Lisdexamfetamine, specifically from 9 to 11 hours (many sources suggest 10.39 hours). Thus, Dextroamphetamine component remains in the body for 2-2.5 days post-ingestion. Other secondary metabolites’ elimination half-life such as the benzoic acid is longer than Lisdexamfetamine.

There are many various factors which contribute to half-life time elimination of the Vyvanse  in your system including:

  • Individual factors: age, body weight, gastrointestinal pH, and renal function.
  • Food and Drink or hydration intake: acidic foods which decrease its absorption. For example, nuts, cranberries, grains, Vitamin C, dairy products, carbonated beverages, etc.
  • Kidney function: those with renal impairment eliminate the medication at a much slower rate in comparison with those with normative renal function.
  • Metabolic rate: taking Vyvanse increases the metabolic rate of a person.
  • Gastrointestinal pH: The pH of gastrointestinal (GI) tract will affect the absorption of Dextroamphetamine.
  • Intake of other drugs: Drugs are considered as the inducers of the aforementioned enzymes may promote metabolism and decrease the elimination half-life of Dextroamphetamine. However, there are also some drugs which can inhibit the elimination of dextroamphetamine from the body system.

How May The Frequency Of Use Vyvanse Influence Its Elimination Half-life?

The frequency of use Vyvanse may influence its elimination half-life. Most patients take the medication once a day. However, some can be prescribed to take Vyvanse twice a day, which is considered as the “high frequency” use. Those high-frequency users may accumulate the Vyvanse concentration within their kidneys before excretion. Thereby, among frequent users, the elimination half-life time of Vyvanse also increases while low-frequency users are less to accumulate the medication concentration in their system.

How To Detect Vyvanse Concentration In Your System?

Vyvanse can be detected by the following tests:

  • Urine testing: depending on your urinary pH, after intake of the medication, its concentration can be detected in your urine between 2.5- 3 days.
  • Hair testing: intake of this medication, hair samples may be collected to test its content in the body system between 1-2 weeks.
  • Saliva testing: Vyvanse can be detected in your saliva for several days after you take it.
  • Blood testing: after taking the medication, blood testing can detect Vyvanse or amphetamines concentration, within 24 hours.


Vyvanse should not be abused because this can cause serious health problems. Hopefully, the information is provided in this article will help you understand more about “How long does Vyvanse stay in your system?” If you are concerned about its side effects and want to keep taking this medication, should follow your doctor’s supervision and recommendation.